The mean daily global solar radiation flux is influenced by astronomical, climatological, geographical, geometrical, meteorological, and physical parameters. This paper deals with the study of the effects of influencing parameters on the mean daily global solar radiation flux, and also with the computation of the solar radiation flux at the surface of the earth in locations without solar radiation measurements. The reference–real data were borrowed from the Iranian Meteorological Organization. The analysis of data showed that the mean daily solar radiation flux on a horizontal surface is related to parameters such as: mean daily extraterrestrial solar radiation, average daily ratio of sunshine duration, mean daily relative humidity, mean daily maximum air temperature, mean daily maximum dew point temperature, mean daily atmospheric pressure, and sine of the solar declination angle. Multiple regression and correlation analysis were applied to predict the mean daily global solar radiation flux on a horizontal surface. The models were validated when compared with the reference–measured data of global solar radiation flux. The results showed that the models estimate the global solar radiation flux within a narrow relative error band. The values of mean bias errors and root mean square errors were within acceptable margins. The predicted values of global solar radiation flux by this approach can be used for the design and performance estimation in solar applications. The model can be used in areas where meteorological stations do not exist and information on solar radiation flux cannot be obtained experimentally.