The present article discusses an overview on the contamination of non-segregated open municipal solid waste (MSW) in and around a dumping site at Garchuk in Guwahati city, Assam, India. Analysis showed depth-wise variations in the concentrations of selected heavy metals in MSW and their subsequent accumulations with increasing depths. Zinc was the most abundant heavy metal in MSW. Six-step selective sequential extractions revealed that most of the heavy metals in MSW were in the residual phase except zinc. Analysis of the leachate from MSW showed high concentrations of fluoride, chloride, ammonium–nitrogen and the ratio of biological oxygen demand/chemical oxygen demand. Concentrations of all the heavy metals in the leachates were higher than the Indian national effluent standards. High amounts of biological oxygen demand, heavy metals, total and fecal coliforms in water samples from the adjoining water body (Deepor Beel, a Ramsar site) of the MSW dumping site indicated its unsuitability for domestic use. Principle component analysis showed that influence of MSW leachate was the major source of water contamination in Deepor Beel. Though accumulation of heavy metals in different vegetables growing in MSW dumping site did not exceed the recommended maximum intake, it was a significant additional source of heavy metals in cooked human diet.