The thermal-power plant with combined heat and power (CHP) production located in the city of Zrenjanin (Serbia) is powered by two steam boilers with nominal power of 280 MW each. Considering the problem of increasing pollutant emissions that occur during fossil-fuel combustion process, which is recognized as an arising problem in the CHP Zrenjanin, the accredited Laboratory has been carrying out monitoring and control of the emission production. The emissions have been measured during winter season on boiler B1 for five working regimes of burners, by adjusting the fuel ratio between natural gas and fuel oil. The measurement has been done regarding carbon monoxide, sulphur dioxide, nitrogen oxides (NOx), particulate matter (PM), gaseous inorganic chlorine compounds denoted as hydrogen chloride, and gaseous inorganic fluoride compounds denoted as hydrogen fluoride. Data acquired from those measurements have shown that all parameters except NOx and PM did not exceed emission limits defined under current regulatory statute. According to data analysis of the flue gas emissions, first preventive actions are recommended, then possible actions that could be taken during combustion process, and as last but not least, actions that have to be applied in case when emission problems appears. Regarding CHP control and management problems, some advices are given emphasizing an integral approach to the analysis and optimization of the CHP as the best solution.